Article
Platelet 12-lipoxygenase Arg261Gln polymorphism: functional characterization and association with risk of esophageal squamous cell carcinoma in combination with COX-2 polymorphisms.
Pharmacogenetics and genomics - 1 Mar 2007
Guo Yongli, Zhang Xuemei, Tan Wen, Miao Xiaoping, Sun Tong, Zhao Dan, Lin Dongxin
Abstract excerpt
BACKGROUND: Aberrant arachidonic acid metabolism by 12-lipoxygenase (12-LOX) and cyclooxygenase-2 (COX-2) has been implicated in human carcinogenesis. Inherited polymorphisms in 12-LOX and COX-2 contributed to differential expression or activity of these enzymes might confer interindividual susceptibility to cancer. OBJECTIVE: To examine the functional significance of 12-LOX 261 Arg> Gln polymorphism and its...
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