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Article

Protein kinase C α enhances migration of breast cancer cells through FOXC2-mediated repression of p120-catenin

1 Dec 2017

Abstract excerpt

BACKGROUND: Despite recent advances in the diagnosis and treatment of breast cancer, metastasis remains the main cause of death. Since migration of tumor cells is considered a prerequisite for tumor cell invasion and metastasis, a pressing goal in tumor biology has been to elucidate factors regulating their migratory activity. Protein kinase C alpha (PKCα) is a serine-threonine protein kinase implicated in cancer...

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Share to Cancer Cells and Metastasis
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Share to Wnt/β-catenin signaling in development and cancer

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PMID: 29216867
DOI: 10.1186/s12885-017-3827-y

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