Article
Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes.
The Journal of biological chemistry - 5 Sept 2003
Soh Jae-Won, Weinstein I Bernard
Abstract excerpt
Although protein kinase C (PKC) has been implicated in cell cycle progression, cell proliferation, and tumor promotion, the precise roles of specific isoforms in these processes is not clear. Therefore, we constructed and analyzed a series of expression vectors that encode hemagglutinin-tagged wild type (WT), constitutively active mutants (Delta NPS and CAT), and dominant negative mutants of PKCs alpha, beta 1,...
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