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Article

Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2006

Ahn Jiyoung, Ambrosone Christine B, Kanetsky Peter A, Tian Chunqiao, Lehman Teresa A, Kropp Silke, Helmbold Irmgard, von Fournier Dietrich, Haase Wulf, Sautter-Bihl Marie Luise, Wenz Frederik, Chang-Claude Jenny

Abstract excerpt

PURPOSE: Because radiotherapy exerts cytotoxic effects via generation of massive oxidative stress, we hypothesized that catalase, manganese superoxide dismutase, myeloperoxidase (MPO), and endothelial nitric oxide synthase (eNOS) genotypes might result in greater risk of radiotoxicity. EXPERIMENTAL DESIGN: Cases (n = 446) were Caucasian women with breast cancer who received radiotherapy following lumpectomy....

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Source

Identifiers

PMID: 17145829
DOI: 10.1158/1078-0432.CCR-06-0039

Genes

MPO
CAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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