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Article

Genetic predictors of acute toxicities related to radiation therapy following lumpectomy for breast cancer: a case-series study.

Breast cancer research : BCR - 1 Jan 2006

Ambrosone Christine B, Tian Chunqiao, Ahn Jiyoung, Kropp Silke, Helmbold Irmgard, von Fournier Dietrich, Haase Wulf, Sautter-Bihl Marie Luise, Wenz Frederik, Chang-Claude Jenny

Abstract excerpt

INTRODUCTION: The cytotoxic effects of radiation therapy are mediated primarily through increased formation of hydroxyl radicals and reactive oxygen species, which can damage cells, proteins and DNA; the glutathione S-transferases (GSTs) function to protect against oxidative stress. We hypothesized that polymorphisms encoding reduced or absent activity in the GSTs might result in greater risk for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16848913
DOI: 10.1186/bcr1526
PMCID: PMC1779469

Genes

GSTP1
GSTA1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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