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Article

Genetic polymorphisms in DNA repair and oxidative stress pathways may modify the association between body size and postmenopausal breast cancer.

Annals of epidemiology - 1 Apr 2015

McCullough Lauren E, Eng Sybil M, Bradshaw Patrick T, Cleveland Rebecca J, Steck Susan E, Terry Mary Beth, Shen Jing, Crew Katherine D, Rossner Pavel, Ahn Jiyoung, Ambrosone Christine B, Teitelbaum Susan L, Neugut Alfred I, Santella Regina M, Gammon Marilie D

Abstract excerpt

PURPOSE: Obesity is associated with increased bioavailability of estrogen, hyperinsulinemia, and chronic inflammation, all of which may promote tumor growth. Given DNA repair and oxidative stress pathways may work together with these mechanisms to influence carcinogenesis, we hypothesized that genetic variation in these pathways may modify the obesity-postmenopausal breast cancer (BC) association. METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25703993
DOI: 10.1016/j.annepidem.2015.01.009
PMCID: PMC4369423

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MPO

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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