Article
Myeloperoxidase genotype, fruit and vegetable consumption, and breast cancer risk.
Cancer research - 15 Oct 2004
Ahn Jiyoung, Gammon Marilie D, Santella Regina M, Gaudet Mia M, Britton Julie A, Teitelbaum Susan L, Terry Mary Beth, Neugut Alfred I, Josephy P David, Ambrosone Christine B
Abstract excerpt
Myeloperoxidase (MPO), an antimicrobial enzyme in the breast, generates reactive oxygen species (ROS) endogenously. An MPO G463A polymorphism exists in the promoter region, with the variant A allele conferring lower transcription activity than the common G allele. Because oxidative stress may play a role in breast carcinogenesis, we evaluated MPO genotypes in relation to breast cancer risk among 1,011 cases and...
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