Article
Oxidative stress-related enzyme gene polymorphisms and susceptibility to breast cancer in non-smoking, non-alcohol-consuming Taiwanese women: a case-control study.
Annals of clinical biochemistry - 1 Mar 2012
Tsai Shih-Meng, Wu Szu-Hsien, Hou Ming-Feng, Chen Yueh-Ling, Ma Hsu, Tsai Li-Yu
Abstract excerpt
BACKGROUND: Mitochondrial manganese superoxide dismutase (MnSOD) converts superoxide anion into H(2)O(2), which is neutralized sequentially by either catalase (CAT) or glutathione peroxidase 1 (Gpx 1) into water or converted into highly reactive hypochlorous acid by myeloperoxidase (MPO). We hypothesize that gene variants for these enzymes might be associated with the risk of breast cancer in non-smoking,...
Topics
- Base Sequence
- Breast Neoplasms
- Case-Control Studies
- DNA Primers
- Epistasis, Genetic
- Female
- Genetic Predisposition to Disease
- Humans
- Oxidative Stress
- Polymorphism, Genetic