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Article

Inhibition of myogenesis by the H-ras oncogene: implication of a role for protein kinase C.

The Journal of cell biology - 1 Aug 1991

Vaidya T B, Weyman C M, Teegarden D, Ashendel C L, Taparowsky E J

Abstract excerpt

Expression of the oncogenic form of H-ras p21 in the mouse myogenic cell line, 23A2, blocks myogenesis and inhibits expression of the myogenic regulatory factor gene, MyoD1. Previous studies from a number of laboratories have demonstrated that the activation of ras p21 is associated with changes...

Topics

Animals
Blotting, Northern
Cell Differentiation
Cell Fusion
Cell Line
Chloramphenicol O-Acetyltransferase
Creatine Kinase
Enzyme Activation
Genes, ras
Kinetics
Mice
Muscles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Protein Kinase C

RNA

Tetradecanoylphorbol Acetate

Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 1714463
DOI: 10.1083/jcb.114.4.809
PMCID: PMC2289900

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1714463-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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