Article
Extracellular signal-regulated kinase-1 and -2 respond differently to mitogenic and differentiative signaling pathways in myoblasts.
Molecular endocrinology (Baltimore, Md.) - 1 Dec 1997
Sarbassov D D, Jones L G, Peterson C A
Abstract excerpt
In this report we show that extracellular signal-regulated kinase-1 and -2 (ERK-1 and -2) respond differently to signals that elicit proliferation and/or differentiation of myoblasts using the C2C12 cell line and nondifferentiating mutant NFB4 cells derived from them. Induction of differentiation...
Topics
- Animals
- Blood Proteins
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Differentiation
- Cell Line
- Enzyme Activation
- GTP-Binding Proteins
- Insulin-Like Growth Factor II
- Mice
- Mitogen-Activated Protein Kinase 1
- Mitogen-Activated Protein Kinase 3
- Mitogen-Activated Protein Kinases
- Mitosis
- Muscle, Skeletal
- Mutation
- Pertussis Toxin
- Phenotype
- Phosphorylation