Article
Differentiation of vascular smooth muscle cells and the regulation of protein kinase C-alpha.
Circulation research - 1 Jan 1995
Haller H, Lindschau C, Quass P, Distler A, Luft F C
Abstract excerpt
Dedifferentiation and proliferation of vascular smooth muscle cells (VSMCs) are important features of atherosclerosis. The molecular mechanisms are largely unclear; however, protein kinase C (PKC) is a key enzyme in the intracellular signaling pathways that mediate this process. We studied the activity and immunoreactivity of PKC-alpha in primary cultures of VSMCs from rat aortas under different conditions of...
Topics
- Actins
- Animals
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Desmin
- Hypertension
- Isoenzymes
- Male
- Muscle, Smooth, Vascular
- Phenotype
- Protein Kinase C