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Article

Mutation of Thr115 in MyoD positively regulates function in murine fibroblasts and human rhabdomyosarcoma cells.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1998

Liu L N, Dias P, Houghton P J

Abstract excerpt

Committed skeletal muscle myoblasts undergo terminal differentiation when shifted from a high-mitogen medium to a low-mitogen medium. However, expression of the myogenic regulatory factor MyoD seems to be similar in proliferating and differentiating cells, suggesting that its function is attenuated in proliferating myoblasts. To further understand the potential mechanisms that may attenuate MyoD function, we have...

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PMID: 9751114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Mutation of Thr115 in MyoD positively regulates function in murine fibroblasts and human rhabdomyosarcoma cells.PMID 9751114Read ↗

Mutant MyoD lacking Cdc2 phosphorylation sites delays M-phase entry.Semantic proximity Read ↗

The Muscle Regulatory Factors MyoD and Myf-5 Undergo Distinct Cell Cycle–specific Expression in Muscle CellsSemantic proximity Read ↗

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Mutant DMPK 3'-UTR transcripts disrupt C2C12 myogenic differentiation by compromising MyoD.Semantic proximity Read ↗

Decreased levels of myotonic dystrophy protein kinase (DMPK) and delayed differentiation in human myotonic dystrophy myoblastsSemantic proximity Read ↗

Reduced differentiation potential of primary MyoD-/- myogenic cells derived from adult skeletal muscle.Semantic proximity Read ↗

PKR is a novel functional direct player that coordinates skeletal muscle differentiation via p38MAPK/AKT pathways.Semantic proximity Read ↗

MyoD1 and Myogenin Expression in Human Neoplasia: A Review and UpdateSemantic proximity Read ↗

Fibroblast growth factor inhibits MRF4 activity independently of the phosphorylation status of a conserved threonine residue within the DNA-binding domain.Semantic proximity Read ↗

Comparison of Genome-Wide Binding of MyoD in Normal Human Myogenic Cells and Rhabdomyosarcomas Identifies Regional and Local Suppression of Promyogenic Transcription FactorsSemantic proximity Read ↗

The triiodothyronine nuclear receptor c-ErbAalpha1 inhibits avian MyoD transcriptional activity in myoblasts.Semantic proximity Read ↗

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