Article
Mutation of Thr115 in MyoD positively regulates function in murine fibroblasts and human rhabdomyosarcoma cells.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 1998
Liu L N, Dias P, Houghton P J
Abstract excerpt
Committed skeletal muscle myoblasts undergo terminal differentiation when shifted from a high-mitogen medium to a low-mitogen medium. However, expression of the myogenic regulatory factor MyoD seems to be similar in proliferating and differentiating cells, suggesting that its function is attenuat...
Topics
- Adenoviridae
- Adenovirus E1 Proteins
- Adenovirus E3 Proteins
- Amino Acid Substitution
- Animals
- Cell Differentiation
- Cloning, Molecular
- Culture Media
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Fibroblasts
- Genetic Vectors
- Giant Cells
- Growth Substances
- Humans
- Mutation
- MyoD Protein
- Recombinant Fusion Proteins