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Article

Sprouty-2 overexpression in C2C12 cells confers myogenic differentiation properties in the presence of FGF2.

Molecular biology of the cell - 1 Sept 2005

de Alvaro Cristina, Martinez Natalia, Rojas Jose M, Lorenzo Margarita

Abstract excerpt

Myoblast C2C12 cells cultured in the presence of FGF2 actively proliferate and showed a differentiation-defective phenotype compared with cells cultured in low serum or in the presence of insulin. These FGF2 effects are associated with sustained activation of p44/p42-MAPK and lack of activation of AKT. Here we demonstrate that Sprouty-2, a protein involved in the negative feedback of receptor tyrosine kinase...

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Topics

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Share to Adaptor Proteins, Signal Transducing
Share to Fibroblast Growth Factor 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Signaling Peptides and Proteins

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Muscle, Skeletal

Share to Myoblasts

Share to Protein Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 16000370
DOI: 10.1091/mbc.e05-05-0419
PMCID: PMC1196351

Genes

FGF2
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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