Article
Positive regulation of skeletal myogenesis by R-Ras.
Oncogene - 24 Feb 2000
Suzuki J, Kaziro Y, Koide H
Abstract excerpt
Most of the proteins in the Ras-family proteins, including Ras, Rap and TC21, have been reported to be strong inhibitors of skeletal myogenesis. Here we show that R-Ras, another member of this family, promotes terminal differentiation of C2C12 skeletal myoblasts. In contrast to Ras, which induced a markedly transformed phenotype of C2C12 cells, an activated mutant of R-Ras (R-RasQ87L) did not exhibit any...
Topics
- Animals
- Cell Death
- Cell Differentiation
- Cell Line
- Cell Movement
- Creatine Kinase
- Enzyme Induction
- GTP Phosphohydrolases
- Gene Expression Regulation
- Mice
- Muscle, Skeletal
- Mutation