Analysis of phospholipid metabolism in murine keratinocytes transformed by the v-ras oncogene: relationship of phosphatidylinositol turnover and cytokine stimulation to the transformed phenotype.

doi:10.1093/carcin/13.12.2367

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Article

Analysis of phospholipid metabolism in murine keratinocytes transformed by the v-ras oncogene: relationship of phosphatidylinositol turnover and cytokine stimulation to the transformed phenotype.

Carcinogenesis - 1 Dec 1992

Lee E, Punnonen K, Cheng C, Glick A, Dlugosz A, Yuspa S H

Abstract excerpt

Introduction of a v-rasHa oncogene into cultured mouse keratinocytes by transduction with a defective retrovirus is sufficient to transform keratinocytes to the benign phenotype. Transduced keratinocytes overexpress TGF alpha and hyperproliferate in culture medium with 0.05 mM Ca2+. Whereas normal keratinocytes respond to elevated medium Ca2+ by cessation of proliferation and induction of terminal...

Topics

Aluminum
Aluminum Compounds
Animals
Calcium
Cell Differentiation
Cell Division
Cell Transformation, Neoplastic
Cells, Cultured
Choline
Cytokines
Diglycerides

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fluorides

Genes, ras

Keratinocytes

Mice

Mice, Inbred BALB C

Mutation

Phenotype

Source

Open in PubMed

Identifiers

PMID: 1473246
DOI: 10.1093/carcin/13.12.2367

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1473246-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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