Article
Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation.
The EMBO journal - 7 Mar 2007
Perdiguero Eusebio, Ruiz-Bonilla Vanessa, Gresh Lionel, Hui Lijian, Ballestar Esteban, Sousa-Victor Pedro, Baeza-Raja Bernat, Jardí Mercè, Bosch-Comas Anna, Esteller Manel, Caelles Carme, Serrano Antonio L, Wagner Erwin F, Muñoz-Cánoves Pura
Abstract excerpt
The p38 mitogen-activated protein kinase (MAPK) pathway plays a critical role in skeletal muscle differentiation. However, the relative contribution of the four p38 MAPKs (p38alpha, p38beta, p38gamma and p38delta) to this process is unknown. Here we show that myoblasts lacking p38alpha, but not those lacking p38beta or p38delta, are unable to differentiate and form multinucleated myotubes, whereas...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.