Article
The pathogenic fungus Cryptococcus neoformans expresses two functional GDP-mannose transporters with distinct expression patterns and roles in capsule synthesis.
Eukaryotic cell - 1 May 2007
Cottrell Tricia R, Griffith Cara L, Liu Hong, Nenninger Ashley A, Doering Tamara L
Abstract excerpt
Cryptococcus neoformans is a fungal pathogen that is responsible for life-threatening disease, particularly in the context of compromised immunity. This organism makes extensive use of mannose in constructing its cell wall, glycoproteins, and glycolipids. Mannose also comprises up to two-thirds of the main cryptococcal virulence factor, a polysaccharide capsule that surrounds the cell. The glycosyltransfer...
Topics
- Amino Acid Sequence
- Antigens, Fungal
- Biological Transport
- Carrier Proteins
- Cryptococcus neoformans
- Gene Expression Regulation, Fungal
- Genetic Complementation Test
- Mannose
- Molecular Sequence Data
- Mutation
- Saccharomyces cerevisiae
- Substrate Specificity