Article
Pan-neural Prospero terminates cell proliferation during Drosophila neurogenesis.
Genes & development - 15 Jan 2000
Li L, Vaessin H
Abstract excerpt
Organogenesis requires coordination between developmental specific regulators and genes governing cell proliferation. Here we show that Drosophila prospero encodes a critical regulator of the transition from mitotically active cells to terminal differentiated neurons. Loss of pros results in aberrant expression of multiple cell-cycle regulatory genes and ectopic mitotic activity. In contrast, ectopic pros...
Topics
- Animals
- Cell Cycle
- Cell Differentiation
- Cell Division
- Drosophila Proteins
- Drosophila melanogaster
- Gene Expression Regulation, Developmental
- Genes, Regulator
- Genes, cdc
- Homeodomain Proteins
- Mutation
- Nerve Tissue Proteins
- Neurons
- Nuclear Proteins
- Transcription Factors
- Transcription, Genetic