Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection.

Thrombosis and haemostasis - 1 Dec 2006

Sardjono Caroline T, Harbour Stacey N, Yip Jana C, Paddock Cathy, Tridandapani Susheela, Newman Peter J, Jackson Denise E

Abstract excerpt

The Ig-ITIM superfamily member, PECAM-1 acts as a negative regulator of ITAM-signalling pathways in platelets involving GPVI/FcR gamma chain and Fc?RIIa. This negative feedback loop involves regulation of collagen and GPVI-dependent aggregation events, platelet-thrombus-growth on immobilised collagen under flow and Fc?RIIa-mediated platelet responses. In this study, we show that PECAM-1 is selectively...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actin Cytoskeleton
Share to Etoposide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Membrane Microdomains

Share to Palmitic Acid

Share to Platelet Activation

Share to Platelet Endothelial Cell Adhesion Molecule-1

Share to Platelet Membrane Glycoproteins

Share to Receptors, IgG

Source

Identifiers

PMID: 17139370

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Palmitoylation at Cys595 is essential for PECAM-1 localisation into membrane microdomains and for efficient PECAM-1-mediated cytoprotection.PMID 17139370Read ↗

Raft localisation of FcgammaRIIa and efficient signaling are dependent on palmitoylation of cysteine 208.Semantic proximity Read ↗

Palmitoylation of protease-activated receptor-1 regulates adaptor protein complex-2 and -3 interaction with tyrosine-based motifs and endocytic sorting.Semantic proximity Read ↗

CD44 sensitivity of platelet activation, membrane scrambling and adhesion under high arterial shear rates.Semantic proximity Read ↗

Platelet endothelial cell adhesion molecule-1 (PECAM-1) homophilic adhesion is mediated by immunoglobulin-like domains 1 and 2 and depends on the cytoplasmic domain and the level of surface expression.Semantic proximity Read ↗

The class II PI 3-kinase, PI3KC2α, links platelet internal membrane structure to shear-dependent adhesive function.Semantic proximity Read ↗

Comparative phenotyping of surface markers and glycans in murine and human platelet-derived extracellular vesicles.Semantic proximity Read ↗

PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization.Semantic proximity Read ↗

Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain.Semantic proximity Read ↗

Targeted recycling of PECAM from endothelial surface-connected compartments during diapedesisSemantic proximity Read ↗

Tetherin/BST2, a physiologically and therapeutically relevant regulator of platelet receptor signallingSemantic proximity Read ↗

Dysfunctional intracellular trafficking in the pathobiology of pulmonary arterial hypertension.Semantic proximity Read ↗

Role of the transmembrane and cytoplasmic domains in the assembly and surface exposure of the platelet integrin GPIIb/IIIa.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.