Article
Raft localisation of FcgammaRIIa and efficient signaling are dependent on palmitoylation of cysteine 208.
Immunology letters - 15 Apr 2006
Barnes N C, Powell M S, Trist H M, Gavin A L, Wines B D, Hogarth P M
Abstract excerpt
Ligand-dependent aggregation of FcgammaRIIa initiates multiple biochemical processes including the translocation to detergent resistant membrane domains (DRMs) and receptor tyrosine phosphorylation. Palmitoylation of cysteine residues is considered to be one process that assists in the localisation of proteins to DRMs. Within the juxtamembrane region of FcgammaRIIa there is cysteine residue (C208) that we show to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.