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Article

PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization.

Blood - 1 Apr 2003

O'Brien Christopher D, Lim Poay, Sun Jing, Albelda Steven M

Abstract excerpt

Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31), a tyrosine phosphoprotein highly expressed on endothelial cells and leukocytes, is an important component in the regulation of neutrophil transendothelial migration. Engagement of endothelial PECAM-1 activates tyrosine phosphorylation events and evokes prolonged calcium transients, while homophilic engagement of neutrophil PECAM-1 activates leukocyte...

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Source

Identifiers

PMID: 12468430
DOI: 10.1182/blood-2002-08-2396

Genes

REN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PECAM-1-dependent neutrophil transmigration is independent of monolayer PECAM-1 signaling or localization.PMID 12468430Read ↗

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