Article
Delineation of the region in the glycoprotein VI tail required for association with the Fc receptor gamma-chain.
The Journal of biological chemistry - 19 Sept 2003
Bori-Sanz Teresa, Inoue Katsue Suzuki, Berndt Michael C, Watson Steve P, Tulasne David
Abstract excerpt
The glycoprotein VI (GPVI).Fc receptor gamma-chain (FcRgamma-chain) complex is the major activation receptor for collagen on platelets. GPVI cross-linking mediates activation through tyrosine phosphorylation of an ITAM (immunoreceptor tyrosine-based activation motif) in the FcR gamma-chain by Src family kinases. It has been previously shown that a transmembrane arginine and the cytoplasmic domain of GPVI are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
