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Article

Signature-tagged mutagenesis: barcoding mutants for genome-wide screens.

Nature reviews. Genetics - 1 Dec 2006

Mazurkiewicz Piotr, Tang Christoph M, Boone Charles, Holden David W

Abstract excerpt

DNA signature tags (molecular barcodes) facilitate functional screens by identifying mutants in mixed populations that have a reduced or increased adaptation to a particular environment. Many innovative adaptations and refinements in the technology have been described since its original use with Salmonella; they have yielded a wealth of information on a broad range of biological processes--mainly in bacteria, but...

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PMID: 17139324
DOI: 10.1038/nrg1984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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