Identification of Burkholderia cenocepacia genes required for bacterial survival in vivo.

doi:10.1128/IAI.72.7.4010-4022.2004

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Article

Identification of Burkholderia cenocepacia genes required for bacterial survival in vivo.

Infection and immunity - 1 Jul 2004

Hunt Tracey A, Kooi Cora, Sokol Pamela A, Valvano Miguel A

Abstract excerpt

Burkholderia cenocepacia (formerly Burkholderia cepacia complex genomovar III) causes chronic lung infections in patients with cystic fibrosis. In this work, we used a modified signature-tagged mutagenesis (STM) strategy for the isolation of B. cenocepacia mutants that cannot survive in vivo. Thirty-seven specialized plasposons, each carrying a unique oligonucleotide tag signature, were constructed and used to...

Topics

Animals
Burkholderia cepacia complex
Chromosome Mapping
DNA Transposable Elements
Electrophoresis, Gel, Two-Dimensional
Lung
Mutation
Polymerase Chain Reaction
Rats

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Identifiers

PMID: 15213146
DOI: 10.1128/IAI.72.7.4010-4022.2004
PMCID: PMC427415

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