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Article

A Signature-Tagged Mutagenesis (STM)-based murine-infectivity assay for Cryptococcus neoformans.

Journal of microbiology (Seoul, Korea) - 1 Oct 2020

Jung Kwang-Woo, Lee Kyung-Tae, Bahn Yong-Sun

Abstract excerpt

Signature-tagged mutagenesis (STM) is a high-throughput genetic technique that can be used to investigate the function of genes by constructing a large number of mutant strains with unique DNA identification tags, pooling them, and screening them for a particular phenotypic trait. STM was first designed for the identification of genes that contribute to the virulence or infectivity of a pathogen in its host....

Topics

Animals
Cryptococcosis
Cryptococcus neoformans
DNA, Fungal
Female
Gene Deletion
Genes, Fungal
Genome, Fungal
Mice
Mice, Inbred A
Phenotype
Virulence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32989639
DOI: 10.1007/s12275-020-0341-8

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