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Article

Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans.

The EMBO journal - 13 Dec 2006

Morita Kiyokazu, Han Min

Abstract excerpt

The timing of postembryonic developmental programs in Caenorhabditis elegans is regulated by a set of so-called heterochronic genes, including lin-28 that specifies second larval programs. lin-66 mutations described herein cause delays in vulval and seam cell differentiation, indicating a role for lin-66 in timing regulation. A mutation in daf-12/nuclear receptor or alg-1/argonaute dramatically enhances the...

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Identifiers

PMID: 17139256
DOI: 10.1038/sj.emboj.7601451
PMCID: PMC1698897

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Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans.PMID 17139256Read ↗

let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.Semantic proximity Read ↗

C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA.Semantic proximity Read ↗

<i>C. elegans</i> LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of <i>lin-46</i> mRNASemantic proximity Read ↗

Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.Semantic proximity Read ↗

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.Semantic proximity Read ↗

Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression.Semantic proximity Read ↗

Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects.Semantic proximity Read ↗

The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.Semantic proximity Read ↗

The zinc-finger protein SEA-2 regulates larval developmental timing and adult lifespan in C. elegans.Semantic proximity Read ↗

The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system.Semantic proximity Read ↗

Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes.Semantic proximity Read ↗

Somatic gonad morphogenesis in C. elegans requires the heterochronic pathway acting through HBL-1.Semantic proximity Read ↗

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