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Article

Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.

Science (New York, N.Y.) - 5 Nov 1999

Jeon M, Gardner H F, Miller E A, Deshler J, Rougvie A E

Abstract excerpt

The Caenorhabditis elegans heterochronic genes control the relative timing and sequence of many events during postembryonic development, including the terminal differentiation of the lateral hypodermis, which occurs during the final (fourth) molt. Inactivation of the heterochronic gene lin-42 causes hypodermal terminal differentiation to occur precociously, during the third molt. LIN-42 most closely resembles the...

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PMID: 10550049
DOI: 10.1126/science.286.5442.1141

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins.PMID 10550049Read ↗

Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42.Semantic proximity Read ↗

Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing.Semantic proximity Read ↗

Developmental timing in C. elegans is regulated by kin-20 and tim-1, homologs of core circadian clock genes.Semantic proximity Read ↗

LIN-42/PERIOD controls cyclical and developmental progression of C. elegans molts.Semantic proximity Read ↗

Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression.Semantic proximity Read ↗

The Period protein homolog LIN-42 regulates germline development in C. elegans.Semantic proximity Read ↗

let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.Semantic proximity Read ↗

LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.Semantic proximity Read ↗

Temporal pattern formation by heterochronic genes.Semantic proximity Read ↗

The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin.Semantic proximity Read ↗

Clock gene homologs lin-42 and kin-20 regulate circadian rhythms in C. elegans.Semantic proximity Read ↗

Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans.Semantic proximity Read ↗

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