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Somatic gonad morphogenesis in C. elegans requires the heterochronic pathway acting through HBL-1.

G3 (Bethesda, Md.) - 8 Oct 2025

Minutillo Madeleine, Kemper Kevin, Ivanova Maria, Pianin Erika, Moss Eric G

Abstract excerpt

Heterochronic genes are known for acting in succession to control the timing of stage-specific events of the developing Caenorhabditis elegans larva. While most heterochronic mutants have normal gonad development, in a few cases, defective timing regulators lead to variations in gonad development, although with little to no effect on fertility. We found that a double mutant of 2 heterochronic genes, a lin-28 null...

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Identifiers

PMID: 40719107
DOI: 10.1093/g3journal/jkaf170
PMCID: PMC12506653

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Somatic gonad morphogenesis in C. elegans requires the heterochronic pathway acting through HBL-1.PMID 40719107Read ↗

Somatic gonad morphogenesis in <i>C. elegans</i> requires the heterochronic pathway acting through HBL-1Semantic proximity Read ↗

The <i>C. elegans</i> heterochronic gene <i>lin-28</i> coordinates the timing of hypodermal and somatic gonadal programs for hermaphrodite reproductive system morphogenesisSemantic proximity Read ↗

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C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA.Semantic proximity Read ↗

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