Article
The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.
Cell - 7 Mar 1997
Moss E G, Lee R C, Ambros V
Abstract excerpt
Mutations in the heterochronic gene lin-28 of C. elegans cause precocious development where diverse events specific to the second larval stage are skipped. lin-28 encodes a cytoplasmic protein with a cold shock domain and retroviral-type (CCHC) zinc finger motifs, consistent with a role for LIN-2...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Chromosome Mapping
- Cloning, Molecular
- Cold Temperature
- Cytoplasm
- Embryonic Induction
- Gene Expression Regulation, Developmental
- Genes, Helminth
- Genotype
- Green Fluorescent Proteins
- Helminth Proteins
- Luminescent Proteins
- Molecular Sequence Data
- Nuclear Proteins
- Phenotype
- Protein Structure, Tertiary