Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.

PLoS genetics - 1 Mar 2015

Cohen Max L, Kim Sunhong, Morita Kiyokazu, Kim Seong Heon, Han Min

Abstract excerpt

Postembryonic development in Caenorhabditis elegans is a powerful model for the study of the temporal regulation of development and for the roles of microRNAs in controlling gene expression. Stable switch-like changes in gene expression occur during development as stage-specific microRNAs are expressed and subsequently down-regulate other stage-specific factors, driving developmental progression. Key genes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caenorhabditis elegans
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Differentiation

Share to GATA Transcription Factors

Share to Gene Expression Regulation, Developmental

Share to MicroRNAs

Share to Receptors, Cytoplasmic and Nuclear

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 25816370
DOI: 10.1371/journal.pgen.1005099
PMCID: PMC4376641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.PMID 25816370Read ↗

Multiple cis-elements and trans-acting factors regulate dynamic spatio-temporal transcription of let-7 in Caenorhabditis elegans.Semantic proximity Read ↗

Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects.Semantic proximity Read ↗

<i>let-7</i> controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41Semantic proximity Read ↗

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans.Semantic proximity Read ↗

let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.Semantic proximity Read ↗

Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.Semantic proximity Read ↗

The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs.Semantic proximity Read ↗

ELT-2 is the predominant transcription factor controlling differentiation and function of the C. elegans intestine, from embryo to adult.Semantic proximity Read ↗

Deactivation of the GATA Transcription Factor ELT-2 Is a Major Driver of Normal Aging in C. elegans.Semantic proximity Read ↗

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.Semantic proximity Read ↗

A developmental timer coordinates organism-wide microRNA transcriptionSemantic proximity Read ↗

Functional genomic analysis of the let-7 regulatory network in Caenorhabditis elegans.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.