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Article

C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA.

Cell reports - 7 Sept 2021

Ilbay Orkan, Nelson Charles, Ambros Victor

Abstract excerpt

Lin28/LIN-28 is a conserved RNA-binding protein that promotes proliferation and pluripotency and can be oncogenic in mammals. Mammalian Lin28 and C. elegans LIN-28 have been shown to inhibit biogenesis of the conserved cellular differentiation-promoting microRNA let-7 by directly binding to unprocessed let-7 transcripts. Lin28/LIN-28 also bind and regulate many mRNAs in diverse cell types. However, the...

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Identifiers

PMID: 34496246
DOI: 10.1016/j.celrep.2021.109670
PMCID: PMC8445076

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA.PMID 34496246Read ↗

<i>C. elegans</i> LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of <i>lin-46</i> mRNASemantic proximity Read ↗

let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.Semantic proximity Read ↗

Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans.Semantic proximity Read ↗

The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin.Semantic proximity Read ↗

Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression.Semantic proximity Read ↗

LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.Semantic proximity Read ↗

The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor.Semantic proximity Read ↗

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Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.Semantic proximity Read ↗

<i>let-7</i> controls the transition to adulthood by releasing select transcriptional regulators from repression by LIN41Semantic proximity Read ↗

Somatic gonad morphogenesis in <i>C. elegans</i> requires the heterochronic pathway acting through HBL-1Semantic proximity Read ↗

Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects.Semantic proximity Read ↗

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