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Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects.

Developmental cell - 1 Sept 2005

Li Ming, Jones-Rhoades Matthew W, Lau Nelson C, Bartel David P, Rougvie Ann E

Abstract excerpt

The C. elegans heterochronic genes program stage-specific temporal identities in multiple tissues during larval development. These genes include the first two miRNA-encoding genes discovered, lin-4 and let-7. We show that lin-58 alleles, identified as lin-4 suppressors, define another miRNA that controls developmental time. These alleles are unique in that they contain point mutations in a gene regulatory element...

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PMID: 16139229
DOI: 10.1016/j.devcel.2005.08.002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects.PMID 16139229Read ↗

The let-7 MicroRNA family members mir-48, mir-84, and mir-241 function together to regulate developmental timing in Caenorhabditis elegans.Semantic proximity Read ↗

let-7 miRNA and lin-46 mRNA are essential targets of the LIN28 RNA-binding protein in Caenorhabditis elegans developmental timing regulation.Semantic proximity Read ↗

Misexpression of the Caenorhabditis elegans miRNA let-7 is sufficient to drive developmental programs.Semantic proximity Read ↗

The GATA factor elt-1 regulates C. elegans developmental timing by promoting expression of the let-7 family microRNAs.Semantic proximity Read ↗

The Caenorhabditis elegans heterochronic gene lin-14 coordinates temporal progression and maturation in the egg-laying system.Semantic proximity Read ↗

The cold shock domain protein LIN-28 controls developmental timing in C. elegans and is regulated by the lin-4 RNA.Semantic proximity Read ↗

Caenorhabditis elegans period homolog lin-42 regulates the timing of heterochronic miRNA expression.Semantic proximity Read ↗

The timing of lin-4 RNA accumulation controls the timing of postembryonic developmental events in Caenorhabditis elegans.Semantic proximity Read ↗

Multiple mechanisms are involved in regulating the expression of the developmental timing regulator lin-28 in Caenorhabditis elegans.Semantic proximity Read ↗

C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA.Semantic proximity Read ↗

<i>C. elegans</i> LIN-28 controls temporal cell-fate progression by regulating LIN-46 expression via the 5’UTR of <i>lin-46</i> mRNASemantic proximity Read ↗

Heterochronic genes control cell cycle progress and developmental competence of C. elegans vulva precursor cells.Semantic proximity Read ↗

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