Article
RecQ helicase and RecJ nuclease provide complementary functions to resect DNA for homologous recombination.
Proceedings of the National Academy of Sciences of the United States of America - 2 Dec 2014
Morimatsu Katsumi, Kowalczykowski Stephen C
Abstract excerpt
Recombinational DNA repair by the RecF pathway of Escherichia coli requires the coordinated activities of RecA, RecFOR, RecQ, RecJ, and single-strand DNA binding (SSB) proteins. These proteins facilitate formation of homologously paired joint molecules between linear double-stranded (dsDNA) and supercoiled DNA. Repair starts with resection of the broken dsDNA by RecQ, a 3'→5' helicase, RecJ, a 5'→3' exonuclease,...
Topics
- DNA Breaks, Double-Stranded
- DNA Repair
- DNA, Bacterial
- DNA, Single-Stranded
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Exodeoxyribonucleases
- Homologous Recombination
- Models, Genetic
- Mutation
- Plasmids
- RecQ Helicases