Article
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk.
BMC cancer - 18 Oct 2010
Campa Daniele, Hüsing Anika, McKay James D, Sinilnikova Olga, Vogel Ulla, Tjønneland Anne, Overvad Kim, Stegger Jakob, Clavel-Chapelon Françoise, Chabbert-Buffet Nathalie, Fagherazzi Guy, Trichopoulou Antonia, Zylis Dimosthenis, Oustoglou Erifili, Rohrmann Sabine, Teucher Birgit, Fisher Eva, Boeing Heiner, Masala Giovanna, Krogh Vittorio, Sacerdote Carlotta, Panico Salvatore, Tumino Rosario, Onland-Moret N Charlotte, van Gils Carla H, Bueno-de-Mesquita H Bas, Lund Eiliv, Chirlaque María Dolores, Sala Núria, Quirós José Ramon, Ardanaz Eva, Amiano Pilar, Molina-Montes Esther, Hallmans Göran, Lenner Per, Travis Ruth C, Key Timothy J, Wareham Nick, Khaw Kay-Tee, Rinaldi Sabina, Slimani Nadia, Chajes Veronique, Siddiq Afshan, Riboli Elio, Kaaks Rudolf, Canzian Federico
Abstract excerpt
BACKGROUND: The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass index (BMI). The first report showing that rs7566605 could be associated with body fatness was a genome-wide association study (GWAS) which used BMI as the primary phenotype. Many follow-up studies sought...
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