Article
Family-based and population-based association studies validate PTPRD as a risk factor for restless legs syndrome.
Movement disorders : official journal of the Movement Disorder Society - 15 Feb 2011
Yang Qinbo, Li Lin, Yang Rong, Shen Gong-Qing, Chen Qiuyun, Foldvary-Schaefer Nancy, Ondo William G, Wang Qing Kenneth
Abstract excerpt
OBJECTIVE: We previously mapped a genetic locus for restless legs syndrome (RLS) to chromosome 9p22-24 (RLS3) and a later genome-wide association study (GWAS) implicated the PTPRD gene at the RLS3 locus as a susceptibility gene for RLS. However, from the standpoint of genetics, the GWAS association needs to be validated by independent studies. In this study, we used both family-based and population-based...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.