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Article

Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila.

Molecular microbiology - 1 Nov 2001

Hilbi H, Segal G, Shuman H A

Abstract excerpt

Legionella pneumophila is the causative agent of Legionnaires' disease, a severe pneumonia. Dependent on the icm/dot loci, L. pneumophila survives and replicates in macrophages and amoebae within a specialized phagosome that does not fuse with lysosomes. Here, we report that phagocytosis of wild-type L. pneumophila is more efficient than uptake of icm/dot mutants. Compared with the wild-type strain JR32, about 10...

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Source

Identifiers

PMID: 11722729
DOI: 10.1046/j.1365-2958.2001.02645.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Icm/dot-dependent upregulation of phagocytosis by Legionella pneumophila.PMID 11722729Read ↗

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The CpxRA two-component system contributes to Legionella pneumophila virulence.Semantic proximity Read ↗

A Legionella pneumophila-translocated substrate that is required for growth within macrophages and protection from host cell death.Semantic proximity Read ↗

Additive effect on intracellular growth by Legionella pneumophila Icm/Dot proteins containing a lipobox motif.Semantic proximity Read ↗

The Legionella pneumophila IcmS-LvgA protein complex is important for Dot/Icm-dependent intracellular growth.Semantic proximity Read ↗

The Legionella pneumophila LidA protein: a translocated substrate of the Dot/Icm system associated with maintenance of bacterial integrity.Semantic proximity Read ↗

Early events in phagosome establishment are required for intracellular survival of Legionella pneumophila.Semantic proximity Read ↗

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Identification of linked Legionella pneumophila genes essential for intracellular growth and evasion of the endocytic pathway.Semantic proximity Read ↗

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