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Article

The Dot/Icm type IV secretion system of Legionella pneumophila is essential for the induction of apoptosis in human macrophages.

Infection and immunity - 1 Mar 2002

Zink Steven D, Pedersen Lisa, Cianciotto Nicholas P, Abu-Kwaik Yousef

Abstract excerpt

We have previously shown that Legionella pneumophila induces caspase 3-dependent apoptosis in mammalian cells during early stages of infection. In this report, we show that nine L. pneumophila strains with mutations in the dotA, dotDCB, icmT, icmGCD, and icmJB loci are completely defective in the induction of apoptosis, in addition to their severe defects in intracellular replication and pore formation-mediated...

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Identifiers

PMID: 11854262
DOI: 10.1128/IAI.70.3.1657-1663.2002
PMCID: PMC127815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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