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Article

Molecular requirements for the mu-induced light chain gene rearrangement in pre-B cells.

The EMBO journal - 1 Aug 1991

Iglesias A, Kopf M, Williams G S, Bühler B, Köhler G

Abstract excerpt

During B cell differentiation rearrangement of immunoglobulin (Ig) genes is partially regulated by the Ig proteins. Rearrangement of heavy (H) chain genes is inhibited, whilst that of light (L) chain genes is induced by the membrane form of the mu H chain. In order to analyse additional structural requirements of mu induced L chain gene rearrangement we transfected wild-type mu and mutant mu constructs lacking...

Topics

Animals
Blotting, Northern
Blotting, Southern
Blotting, Western
Cell Transformation, Neoplastic
DNA
Electrophoresis, Polyacrylamide Gel
Flow Cytometry
Gene Expression Regulation
Gene Rearrangement, B-Lymphocyte, Heavy Chain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Gene Rearrangement, B-Lymphocyte, Light Chain

Immunoglobulin Light Chains

Immunoglobulin Light Chains, Surrogate

Immunoglobulin mu-Chains

Membrane Glycoproteins

Mice

Mice, Transgenic

Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 1712291
DOI: 10.1002/j.1460-2075.1991.tb07749.x
PMCID: PMC452902

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1712291-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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