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Article

Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells.

Immunological reviews - 1 Jun 2000

Melchers F, ten Boekel E, Seidl T, Kong X C, Yamagami T, Onishi K, Shimizu T, Rolink A G, Andersson J

Abstract excerpt

During B-cell development the surrogate light (SL) chain is selectively expressed in progenitor and precursor B cells during the developmental stages of D(H) to J(H) and V(H) to D(H)J(H) rearrangements. Approximately half of all muH chains produced by these rearrangements cannot pair with SL chains and cannot form a pre-B-cell receptor (pre-BCR). A spectrum of affinities between VpreB and individual V(H) domains...

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Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain
Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Immunoglobulin Heavy Chains

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Share to Receptors, Antigen, B-Cell

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Identifiers

PMID: 10933589

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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