Article
Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points.
The American journal of surgical pathology - 1 Dec 2006
O'Brien Michael J, Yang Shi, Mack Charline, Xu Huihong, Huang Christopher S, Mulcahy Elizabeth, Amorosino Mark, Farraye Francis A
Abstract excerpt
The aim of this study was to compare BRAF and KRAS, CpG island methylator phenotype (CIMP), and microsatellite instability (MSI) status in each of the histologic categories, including end-point carcinomas with residual adenoma, of the serrated polyp neoplasia pathway and the traditional (nonserrated) adenoma-carcinoma sequence. Deoxyribonucleic acid (DNA) was extracted from the selected samples and assayed for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.