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Article

The serrated pathway to colorectal carcinoma: current concepts and challenges

27 Oct 2012

Abstract excerpt

Approximately 30% of colorectal carcinomas develop via a serrated neoplasia pathway, named for the pattern of crypts in the precursor polyps. Molecular abnormalities consistently involve methylation of CpG islands [CpG island methylator phenotype (CIMP)] of low degree (CIMP-L) or high degree (CIMP-H), and activating mutations of the mitogen-activated protein kinase pathway components BRAF or KRAS. Microsatellite...

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PMID: 23339363
DOI: 10.1111/his.12055

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