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Article

Clinicopathological and molecular features of sessile serrated adenomas with dysplasia or carcinoma.

Gut - 1 Jan 2017

Bettington Mark, Walker Neal, Rosty Christophe, Brown Ian, Clouston Andrew, McKeone Diane, Pearson Sally-Ann, Leggett Barbara, Whitehall Vicki

Abstract excerpt

OBJECTIVE: Sessile serrated adenomas (SSAs) are the precursors of at least 15% of colorectal carcinomas, but their biology is incompletely understood. We performed a clinicopathological and molecular analysis of a large number of the rarely observed SSAs with dysplasia/carcinoma to better define their features and the pathways by which they progress to carcinoma. DESIGN: A cross-sectional analysis of 137 SSAs...

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Identifiers

PMID: 26475632
DOI: 10.1136/gutjnl-2015-310456

Genes

BRAF
MLH1
KRAS
MGMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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