Article
Phenotypic alterations and cytokine production in THP-1 cells in response to allergens.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Apr 2007
Miyazawa Masaaki, Ito Yuichi, Yoshida Yukiko, Sakaguchi Hitoshi, Suzuki Hiroyuki
Abstract excerpt
In the induction phase of allergic contact hypersensitivity, dendritic cells (DCs), including Langerhans cells (LCs) present in epidermis, can trigger an efficient T cell response once they have matured in response to an allergen. Upon maturation, DCs have been shown to induce expression of several surface molecules and the up-regulation of cytokine production. We have previously shown that THP-1 cells, human...
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