Article
Modulation of phenotype, cytokine production and stimulatory function of CD34+-derived DC by NiCl(2) and SDS.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Jan 2000
De Smedt A C, Van Den Heuvel R L, Zwi Berneman N, Schoeters G E
Abstract excerpt
One of the most promising alternatives to identify the sensitizing potency of new products is the in vitro culture of human dendritic cells (DC). In vivo, dendritic cells present in the skin are highly specialized antigen-presenting cells (APC) of the immune system, which play a crucial role in the induction of allergic reactions. The DC produce specific cytokines and upregulate specific co-stimulatory molecules...
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