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Article

Role of MAPK signaling pathway in the activation of dendritic type cell line, THP-1, induced by DNCB and NiSO4.

The Journal of toxicological sciences - 1 Feb 2008

Miyazawa Masaaki, Ito Yuichi, Kosaka Nanae, Nukada Yuko, Sakaguchi Hitoshi, Suzuki Hiroyuki, Nishiyama Naohiro

Abstract excerpt

The activation of dendritic cells (DC), including Langerhans cells (LC) that reside within the epidermis, is a critical event in the induction phase of allergic contact hypersensitivity. Although recently, p38 mitogen-activated protein kinase (MAPK) has been reported to play a role in the activation of DC induced by allergens, the signaling pathways involved in this process have yet to be determined. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 18303184
DOI: 10.2131/jts.33.51

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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