Article
p38 Mitogen-activated protein kinase and extracellular signal-regulated kinases play distinct roles in the activation of dendritic cells by two representative haptens, NiCl2 and 2,4-dinitrochlorobenzene.
The Journal of investigative dermatology - 1 Mar 2003
Aiba Setsuya, Manome Hideaki, Nakagawa Satoshi, Mollah Zia U A, Mizuashi Masato, Ohtani Tomoyuki, Yoshino Yumiko, Tagami Hachiro
Abstract excerpt
Previous studies have demonstrated that haptens induce several phenotypic and functional changes of dendritic cells in vivo as well as in vitro. Although recently, the crucial role of p38 mitogen-activated protein kinase has been reported in the activation of dendritic cells by haptens, the signal transduction elements involved in each phenotypic and functional changes that occur in the activation of dendritic...
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