Article
Differential effects of allergens and irritants on early differentiating monocyte-derived dendritic cells.
European journal of dermatology : EJD - 1 Jan 2000
Furio Laetitia, Guezennec Anne, Ducarre Blandine, Guesnet Joelle, Peguet-Navarro Josette
Abstract excerpt
Phenotypic modifications induced by contact allergens on monocyte-derived dendritic cells (MoDC) have been proposed as an in vitro alternative method to discriminate potential sensitizers from irritants. However, the sensitivity of the assay remains controversial. In all the studies reported so far, DC treatment with chemicals was carried out after 5 to 6 days of monocyte culture. Here, we first determined the...
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