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Article

Role of TNF-alpha and extracellular ATP in THP-1 cell activation following allergen exposure.

The Journal of toxicological sciences - 1 Feb 2008

Miyazawa Masaaki, Ito Yuichi, Kosaka Nanae, Nukada Yuko, Sakaguchi Hitoshi, Suzuki Hiroyuki, Nishiyama Naohiro

Abstract excerpt

Dendritic cells (DCs), including Langerhans cells (LCs), play a critical role in the induction phase of allergic contact hypersensitivity. Following exposure to chemical allergens in the skin, LCs undergo a maturation process leading to the up-regulation of expression of co-stimulatory molecules, such as CD86, CD54 and CD40. Our previous study revealed that chemical allergens induce phenotype alterations (e.g.,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18303186
DOI: 10.2131/jts.33.71

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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