Article
Role of TNF-alpha and extracellular ATP in THP-1 cell activation following allergen exposure.
The Journal of toxicological sciences - 1 Feb 2008
Miyazawa Masaaki, Ito Yuichi, Kosaka Nanae, Nukada Yuko, Sakaguchi Hitoshi, Suzuki Hiroyuki, Nishiyama Naohiro
Abstract excerpt
Dendritic cells (DCs), including Langerhans cells (LCs), play a critical role in the induction phase of allergic contact hypersensitivity. Following exposure to chemical allergens in the skin, LCs undergo a maturation process leading to the up-regulation of expression of co-stimulatory molecules, such as CD86, CD54 and CD40. Our previous study revealed that chemical allergens induce phenotype alterations (e.g.,...
Topics
- Adenosine Triphosphate
- Allergens
- B7-2 Antigen
- CD40 Antigens
- Cell Line
- Cell Survival
- Dendritic Cells
- Haptens
- Humans
- Intercellular Adhesion Molecule-1
- Interleukin-8
- Phenotype
- Purinergic P2 Receptor Antagonists
- Recombinant Proteins
- Suramin
- Tumor Necrosis Factor-alpha