Article
Evaluation of CD86 expression and MHC class II molecule internalization in THP-1 human monocyte cells as predictive endpoints for contact sensitizers.
Toxicology in vitro : an international journal published in association with BIBRA - 1 Dec 2002
Ashikaga T, Hoya M, Itagaki H, Katsumura Y, Aiba S
Abstract excerpt
The aim of this study was to explore the usefulness of a human monocyte cell line in the development of in vitro models for predictive testing of contact sensitizers. Several studies have shown that contact sensitizers induce CD86 expression and enhanced internalization of MHC class II molecules in dendritic cells (DCs). We used THP-1, a human monocyte cell line, as a replacement for DCs for evaluation of these...
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