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Article

Gfi-1 plays an important role in IL-2-mediated Th2 cell expansion.

Proceedings of the National Academy of Sciences of the United States of America - 28 Nov 2006

Zhu Jinfang, Jankovic Dragana, Grinberg Alex, Guo Liying, Paul William E

Abstract excerpt

Enforced expression of growth factor independent 1 (Gfi-1), a transcription repressor induced by T cell activation and IL-4/Stat6 signaling, strikingly enhances Th2 cell expansion. Using conditionally Gfi1-deficient mice prepared for this study, we show that in vitro or in vivo deletion of this factor dramatically reduces Th2, but not Th1, cell expansion in response to IL-2. Both increased cell apoptosis and...

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Identifiers

PMID: 17116877
DOI: 10.1073/pnas.0608981103
PMCID: PMC1654136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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